In recent years, there has been a growing emphasis on inflammaging within the realm of skincare, and this focus is well-founded. Inflammation serves as a vital immune response, signalling the body to initiate healing processes and defend against harmful pathogens such as viruses and bacteria. However, when inflammation becomes chronic and excessive, it can result in more harm than good.


Effects of Inflammation:


Various factors contribute to chronic inflammation, including exposure to environmental pollutants like sunlight, smoke, and chemicals, as well as internal stressors such as an unhealthy diet, insufficient sleep, and mental stress. This prolonged inflammation can lead to a condition known as inflammaging, wherein the body remains in a constant state of low-grade inflammation, impairing its ability to repair and regenerate tissue effectively.

Rick Woodin, Chief Scientist at ZO Skin Health, explains that accumulative damage from external and internal sources prevents the skin from functioning optimally, resulting in chronic skin issues and inflammaging. Unlike more visible inflammatory conditions like acne or eczema, inflammaging initially presents as subtle symptoms such as dehydration, sagging, uneven skin tone, and the development of lines and wrinkles.

Woodin further highlights the role of inflammasomes, immune system receptors responsible for regulating inflammation. Instead of suppressing these inflammasomes, the goal is to prevent them from becoming overactive, which occurs when the skin’s antioxidant defenses are overwhelmed by oxidative stress.


“The constant, low-grade thrum of inflammation tires out your skin’s defenses, its ability to heal and renew itself.


Preventative Skincare:


What is ZO’s solution to help protect the skin against signs of premature skin aging caused by inflammation?

Preventative skincare is the solution to preserving the skin’s natural reparative functions that help maintain, and extend, the skin’s youthful appearance. Using preventative skincare products along with corrective solutions helps ensure maximum results as the skin is not impeded by external factors from focusing on restoring the vital components need to optimize skin health.

Next-generation Daily Power Defense is specifically formulated to defend the skin against premature signs of aging by visibly addressing the effects of inflammation:

  • Defends skin against oxidative damage from free radicals
  • Visibly reduces signs of premature aging
  • Accelerates barrier restoration + extended skin hydration
  • Supports continuously healthy skin
Key Ingredients:
  • Antioxidants – as the first line of defence against inflammation, they neutralize the effects of oxidative stress accumulated from internal and external aggressors. Read our post “The Importance of Antioxidants” to learn more about the role of antioxidants in skincare.
  • ZO-RRS2® – a plant stem cell complex, found exclusively in a number of ZO® products, helps to further neutralize free radicals while improving the appearance of skin redness.
  • ZPOLY™ – a plant-derived polysaccharide complex, ZO’s newest exclusive technology infuses the skin with extended hydration while minimizing the signs of premature aging.


Designed for use both morning and night, this lightweight Daily Power Defense serum is suitable for all skin types and tones. Its innovative formula represents a significant advancement in combating inflammaging and promoting overall skin health.


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